1. HMG-CoA reductase null alleles or mutations, simvastatin therapy may actually be toxic. 2. These 4 microsatellite loci were all prone to null alleles . 3. However, with the presence of these null alleles , the results may have been slightly biased. 4. Thus we may consider the allele for the O blood type as a null allele . 5. DRB1 * 0710N is a null allele . 6. Alternatively, the technique can be used to create null alleles so that the gene is not functional. 7. However, the frequency of heterozygous null alleles is much higher than expected, indicating a heterozygous advantage for TPI null alleles . 8. However, the frequency of heterozygous null alleles is much higher than expected, indicating a heterozygous advantage for TPI null alleles. 9. In fact, the mutants for these genes do not show the usual phenotype, that of the null alleles of A genes. 10. Other mutations, which inactivate the enzyme ( = null alleles ) are lethal when inherited heterozygotes ( one defective and one normal copy ).
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